Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DCTPP1 | Q9H773 | 5/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2267584 | 0.78 | LMNA (0.42) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL803098 | 0.78 | ALDH1A1 (0.47) | ALDH1A1TSHRMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL29367224 | 0.78 | ALDH1A1 (0.50) | ALDH1A1TSHRMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL563664 | 0.78 | ALDH1A1 (0.50) | ALDH1A1TSHRMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL1625586 | 0.78 | ALDH1A1 (0.50) | ALDH1A1TSHRMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL29672031 | 0.78 | ALDH1A1 (0.50) | ALDH1A1TSHRMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL5763814 | 0.75 | ALDH1A1 (0.47) | ALDH1A1TSHRMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8811728 | 0.72 | ALDH1A1 (0.44) | ALDH1A1TSHRMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL18031283 | 0.72 | ALDH1A1 (0.44) | ALDH1A1TSHRMAPTMEN1KMT2A | |
| SCHEMBL2267649 | 0.72 | MAPT (0.49) | ALDH1A1TSHRMAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110201629-A1 | CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2011-08-18 | — | — | US | disclosed |
| WO-2011092293-A2 | CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2011-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201629-A1 | CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | CRHR1, CRHR2, CRH | ALDH1A1 3055/4885TSHR 117/4885MAPT 4066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.