Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.44 |
| ▸ | TARBP2 | Q15633 | 3/20 | 0.42 |
| ▸ | PDCD4 | Q53EL6 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28297325 | 0.85 | KDM4E (0.60) | KDM4ESMN1; SMN2TP53HSD17B10ALDH1A1 | |
| SCHEMBL22678319 | 0.85 | PIN1 (0.62) | KDM4EALDH1A1LMNAGAANPSR1 | |
| SCHEMBL4382123 | 0.84 | KDM4E (0.57) | KDM4ESMN1; SMN2TP53HSD17B10POLB | |
| SCHEMBL27475261 | 0.80 | PIN1 (0.68) | KDM4ESMN1; SMN2TP53HSD17B10ALDH1A1 | |
| SCHEMBL17803252 | 0.80 | KDM4E (0.58) | KDM4ESMN1; SMN2TP53HSD17B10ALDH1A1 | |
| SCHEMBL22658075 | 0.76 | TARBP2 (0.73) | KDM4ESMN1; SMN2HSD17B10ALDH1A1LMNA | |
| SCHEMBL22658109 | 0.74 | TARBP2 (0.51) | KDM4ESMN1; SMN2HSD17B10ALDH1A1LMNA | |
| SCHEMBL15864834 | 0.72 | CA12 (0.58) | SMN1; SMN2ALDH1A1LMNAHPGDPOLB | |
| SCHEMBL22678248 | 0.72 | MAPT (0.46) | SMN1; SMN2LMNANPSR1MAPTHTT | |
| SCHEMBL2817928 | 0.72 | ALOX5 (0.54) | KDM4ESMN1; SMN2TP53HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114127049-A | ACSS2 inhibitors and methods of use thereof | 美特波米德有限公司 | 2022-03-01 | — | — | CN | disclosed |
| WO-2020230134-A1 | ACSS2 INHIBITORS AND METHODS OF USE THEREOF | METABOMED LTD (IL) | 2020-11-19 | — | — | WO | disclosed |