Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 3/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30534778 | 0.82 | DRD2 (0.52) | KCNH2DRD2DRD1DRD4DRD5 | |
| SCHEMBL3339233 | 0.82 | DRD2 (0.52) | KCNH2DRD2DRD1DRD4DRD5 | |
| Hydrochloric Acid SCHEMBL29836377 | 0.80 | KCNH2 (0.53) | KCNH2DRD2DRD1DRD4DRD5 | |
| SCHEMBL22681650 | 0.80 | PRKAB2 (0.43) | KCNH2KDM4CPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL22681646 | 0.78 | AXL (0.47) | KCNH2KDM4CPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL31432671 | 0.77 | DRD2 (0.51) | KCNH2DRD2DRD1DRD4DRD5 | |
| SCHEMBL28136178 | 0.75 | SYK (0.38) | KDM4CDRD2DRD1DRD5DRD3 | |
| SCHEMBL22682013 | 0.75 | CTNNB1 (0.53) | KCNH2KDM4CALDH1A1LMNACTNNB1 | |
| SCHEMBL17361810 | 0.74 | KDM4C (0.58) | KDM4CBACE1CTSD | |
| SCHEMBL578280 | 0.73 | KDM4E (0.44) | KCNH2DRD2DRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3160952-B1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2020-12-02 | — | — | EP | disclosed |
| EP-3741749-A1 | HISTONE DEMETHYLASE INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2020-11-25 | — | — | EP | disclosed |
| EP-3738960-A1 | HISTONE DEMETHYLASE INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2020-11-18 | — | — | EP | disclosed |