SCHEMBL2268371

SCHEMBL2268371

CN(C)C(CCC[SiH2]c1ccccc1)N(C)C

nearest known ligand 0.35

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 3/20 0.35
HRH1 P35367 3/20 0.35
NPC1 O15118 1/20 0.34
MAPT P10636 1/20 0.34
MAPK1 P28482 1/20 0.34
HTT P42858 1/20 0.34
RAB9A P51151 1/20 0.34
ATM Q13315 1/20 0.34
SIGMAR1 Q99720 4/20 0.32
TDP1 Q9NUW8 1/20 0.31
AOC3 Q16853 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2269242 0.82 SIGMAR1 (0.35) HTR2AHRH1SIGMAR1
SCHEMBL29404222 0.79 ALDH1A1 (0.37) HTR2AHRH1NPC1HTTRAB9A
SCHEMBL29926801 0.77 ALDH1A1 (0.32) MAPTMAPK1HTTSIGMAR1TDP1
SCHEMBL2102988 0.76 HTR2A (0.35) HTR2AHRH1NPC1MAPTMAPK1
SCHEMBL6057961 0.75 HRH1 (0.47) HTR2AHRH1SIGMAR1
SCHEMBL2268970 0.74 HTR2A (0.35) HTR2AHRH1SIGMAR1
SCHEMBL6443439 0.72 DNM1 (0.40) MAPK1HTTSIGMAR1
SCHEMBL6443323 0.72 DNM1 (0.40) MAPK1HTTSIGMAR1
SCHEMBL6445686 0.72 DNM1 (0.40) MAPK1HTTSIGMAR1
SCHEMBL9665893 0.72 DNM1 (0.40) MAPK1HTTSIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8404584-B2 Method of manufacturing semiconductor device FUJITSU LIMITED (JP) 2013-03-26 US disclosed
US-20110207319-A1 METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE FUJITSU LIMITED (JP) 2011-08-25 US disclosed