Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 6/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 4/20 | 0.37 |
| ▸ | GABBR2 | O75899 | 5/20 | 0.36 |
| ▸ | GABBR1 | Q9UBS5 | 5/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22686795 | 0.76 | BTK (0.38) | PDE2ABTKIDO1HDAC3HDAC1 | |
| SCHEMBL22686796 | 0.76 | BTK (0.38) | PDE2ABTKIDO1GABBR2GABBR1 | |
| SCHEMBL22685308 | 0.74 | PDE10A (0.40) | BTKIDO1 | |
| SCHEMBL22685253 | 0.73 | PDE2A (0.42) | PDE2ABTKIDO1HDAC3HDAC1 | |
| SCHEMBL22685312 | 0.72 | BTK (0.38) | PDE2ABTKIDO1HDAC3HDAC1 | |
| SCHEMBL23908259 | 0.70 | IDO1 (0.45) | PDE2AIDO1 | |
| SCHEMBL22685245 | 0.70 | MAP4K4 (0.41) | PDE2AIDO1 | |
| SCHEMBL22685089 | 0.69 | PDE2A (0.43) | PDE2ABTKHDAC3HDAC1HDAC2 | |
| SCHEMBL22685196 | 0.68 | WDR91 (0.42) | PDE2ABTK | |
| SCHEMBL22685330 | 0.67 | CXCR3 (0.42) | PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020228823-A1 | NOVEL AMIDE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2020-11-19 | — | — | WO | disclosed |