Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 11/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22685312 | 0.78 | BTK (0.38) | PDE2AHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22685252 | 0.78 | PDE2A (0.32) | PDE2AHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22685163 | 0.77 | PDE2A (0.44) | PDE2AHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22685238 | 0.76 | HDAC3 (0.47) | HDAC3HDAC1HDAC2HDAC6BTK | |
| SCHEMBL22685237 | 0.75 | BTK (0.41) | PDE2AHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22685206 | 0.74 | PDE2A (0.48) | PDE2AHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22685235 | 0.74 | CLK1 (0.35) | IDO1 | |
| SCHEMBL22684797 | 0.73 | PDE2A (0.39) | PDE2AHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22686819 | 0.71 | TP53 (0.46) | HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22685089 | 0.71 | PDE2A (0.43) | PDE2AHDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020228823-A1 | NOVEL AMIDE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2020-11-19 | — | — | WO | disclosed |