Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.46 |
| ▸ | CA9 | Q16790 | 4/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.34 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | MLYCD | O95822 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7062593 | 0.86 | CA1 (0.50) | CA12CA9CA2TSHRALDH1A1 | |
| SCHEMBL7497247 | 0.83 | CA12 (0.44) | CA12CA9CA2TSHRMAPK1 | |
| SCHEMBL9462283 | 0.82 | CA12 (0.48) | CA12CA9CA2TSHRMAPK1 | |
| SCHEMBL20472201 | 0.80 | CA12 (0.46) | CA12CA9CA2TSHRMAPK1 | |
| SCHEMBL3898588 | 0.79 | LMNA (0.40) | CA12CA9CA2ALDH1A1CA1 | |
| SCHEMBL24406281 | 0.78 | CA12 (0.44) | CA12CA9CA2TSHRMAPK1 | |
| SCHEMBL6201950 | 0.78 | CA12 (0.44) | CA12CA9CA2TSHRMAPK1 | |
| SCHEMBL21065447 | 0.78 | CA12 (0.44) | CA12CA9CA2TSHRMAPK1 | |
| SCHEMBL9873959 | 0.78 | CA12 (0.44) | CA12CA9CA2TSHRMAPK1 | |
| SCHEMBL4588825 | 0.78 | CA12 (0.44) | CA12CA9CA2TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3741757-B1 | DIHYDROINDOLIZINONE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2023-07-26 | — | — | EP | disclosed |
| US-11530211-B2 | Dihydroindolizinone derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2022-12-20 | — | — | US | disclosed |
| EP-3998107-A1 | METHOD FOR PRODUCING INSULIN-PRODUCING CELL USING DIHYDROINDOLIZINONE DERIVATIVES | Tokyo Institute of Technology (JP) | 2022-05-18 | — | — | EP | disclosed |
| US-20210053965-A1 | DIHYDROINDOLIZINONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2021-02-25 | — | — | US | disclosed |
| WO-2021006268-A1 | METHOD FOR PRODUCING INSULIN-PRODUCING CELL USING DIHYDROINDOLIZINONE DERIVATIVES | 国立大学法人東京工業大学 | 2021-01-14 | — | — | WO | disclosed |
| EP-3741757-A1 | DIHYDROINDOLIZINONE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2020-11-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11530211-B2 | Dihydroindolizinone derivative | INSR, GPR119, IAPP | CA12 3048/4885CA9 3523/4885CA2 1700/4885 |
| US-20210053965-A1 | DIHYDROINDOLIZINONE DERIVATIVE | INSR, GPR119, IAPP | CA12 3048/4885CA9 3523/4885CA2 1700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.