Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 3/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22686792 | 0.80 | PDE2A (0.43) | AKT1CXCR3BTKPDE2AABL1 | |
| SCHEMBL22685090 | 0.75 | CD274 (0.43) | AKT1CTSLCTSBCTSSEGLN1 | |
| SCHEMBL22685308 | 0.75 | PDE10A (0.40) | CTSLCTSBCTSSEGLN1BTK | |
| SCHEMBL22685322 | 0.74 | ROCK2 (0.38) | AKT1CTSLCTSBCTSSEGLN1 | |
| SCHEMBL22685310 | 0.74 | MELK (0.38) | CTSLCTSBCTSSEGLN1BTK | |
| SCHEMBL22685306 | 0.74 | IDO1 (0.41) | AKT1CXCR3CTSLCTSBCTSS | |
| SCHEMBL22686780 | 0.74 | ROCK2 (0.37) | AKT1CTSLCTSBCTSSEGLN1 | |
| SCHEMBL22685309 | 0.73 | ROCK2 (0.38) | AKT1CTSLCTSBCTSSEGLN1 | |
| SCHEMBL22685305 | 0.72 | MKNK1 (0.41) | AKT1CXCR3CTSLCTSBCTSS | |
| SCHEMBL22657417 | 0.71 | MKNK1 (0.45) | AKT1CXCR3CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020228823-A1 | NOVEL AMIDE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2020-11-19 | — | — | WO | disclosed |