Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22685306 | 0.79 | IDO1 (0.41) | CTSLCTSBCTSSCXCR3AKT1 | |
| SCHEMBL22685085 | 0.72 | AKT1 (0.38) | ABL1CTSLCTSBCTSSCXCR3 | |
| SCHEMBL22685302 | 0.71 | CTSL (0.37) | CTSLCTSBCTSSCXCR3ROCK2 | |
| SCHEMBL22686792 | 0.71 | PDE2A (0.43) | ABL1CXCR3AKT1 | |
| SCHEMBL22685301 | 0.69 | CTSL (0.40) | CYP2C8KCNH2CYP3A4CTSLCTSB | |
| SCHEMBL22685090 | 0.69 | CD274 (0.43) | CTSLCTSBCTSSAKT1HDAC6 | |
| SCHEMBL22657417 | 0.68 | MKNK1 (0.45) | MKNK1MKNK2ABL1CTSLCTSB | |
| SCHEMBL22684819 | 0.68 | PTPN1 (0.42) | CYP2C8KCNH2CYP3A4CTSLCTSB | |
| SCHEMBL22657413 | 0.68 | DEGS1 (0.42) | ABL1CTSLCTSBCTSS | |
| SCHEMBL22686795 | 0.68 | BTK (0.38) | ABL1CTSLCTSBCTSSAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020228823-A1 | NOVEL AMIDE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2020-11-19 | — | — | WO | disclosed |