Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.33 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.33 |
| ▸ | HIPK3 | Q9H422 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | POLQ | O75417 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22685202 | 0.72 | WDR91 (0.40) | MAP4K1MAP4K4 | |
| SCHEMBL22438850 | 0.72 | EGLN1 (0.44) | CYP11B1CYP11B2MAP4K4 | |
| SCHEMBL30546855 | 0.68 | POLB (0.51) | EGLN2CYP11B1CYP11B2KDM4EALDH1A1 | |
| SCHEMBL29248897 | 0.68 | POLB (0.51) | EGLN2CYP11B1CYP11B2KDM4EALDH1A1 | |
| SCHEMBL24572229 | 0.66 | ESR2 (0.41) | EGLN2CHEK1 | |
| SCHEMBL1643568 | 0.66 | NOS3 (0.44) | EGLN2OPRM1OPRL1CHEK1POLQ | |
| SCHEMBL16455701 | 0.65 | CYP11B2 (0.49) | EGLN2CYP11B1CYP11B2POLQMAP4K4 | |
| SCHEMBL19901149 | 0.65 | EGLN2 (0.48) | EGLN2CHEK1KDM4EALDH1A1HPGD | |
| SCHEMBL703760 | 0.64 | CYP2A6 (0.46) | OPRM1OPRL1ALDH1A1 | |
| SCHEMBL22685235 | 0.64 | CLK1 (0.35) | CYP11B1CYP11B2CLK1CLK2HIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020228823-A1 | NOVEL AMIDE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2020-11-19 | — | — | WO | disclosed |