Triphosphate

Triphosphate

SCHEMBL2268534

NN.O=P(O)(O)OP(=O)(O)OP(=O)(O)O

nearest known ligand 0.60

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Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
FDPS P14324 1/20 0.60
BLM P54132 1/20 0.60
TDP1 Q9NUW8 1/20 0.60
BTN3A1 O00481 5/20 0.41
CA4 P22748 1/20 0.38
MVD P53602 3/20 0.35
FNTA P49354 1/20 0.31
FNTB P49356 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Triphosphate SCHEMBL15555988 0.93 FDPS (0.69) FDPSBLMTDP1BTN3A1CA4
Triphosphate SCHEMBL18714 0.93 FDPS (0.69) FDPSBLMTDP1BTN3A1CA4
Triphosphate SCHEMBL5324872 0.90 FDPS (0.56) FDPSBLMTDP1BTN3A1CA4
Triphosphate SCHEMBL36119 0.89 FDPS (0.64) FDPSBLMTDP1BTN3A1CA4
Triphosphate SCHEMBL22717549 0.89 FDPS (0.64) FDPSBLMTDP1BTN3A1CA4
Triphosphate SCHEMBL25284822 0.89 FDPS (0.64) FDPSBLMTDP1BTN3A1CA4
Triphosphate SCHEMBL11149492 0.89 FDPS (0.64) FDPSBLMTDP1BTN3A1CA4
Triphosphate SCHEMBL21246913 0.89 FDPS (0.64) FDPSBLMTDP1BTN3A1CA4
SCHEMBL897837 0.89 FDPS (0.64) FDPSBLMTDP1BTN3A1CA4
Triphosphate SCHEMBL3385312 0.89 FDPS (0.64) FDPSBLMTDP1BTN3A1CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999098-B2 Triphosphate oligonucleotide modification reagents and uses thereof SOLULINK BIOSCIENCES, INC. (US) 2011-08-16 US disclosed
US-20070179288-A1 Triphosphate oligonucleotide modification reagents and uses thereof AUDAX PRIVATE DEBT LLC, AS AGENT 2007-08-02 US disclosed
US-7173125-B2 Triphosphate oligonucleotide modification reagents and uses thereof AUDAX PRIVATE DEBT LLC, AS AGENT 2007-02-06 US disclosed
US-20040214199-A1 Triphosphate oligonucleotide modification reagents and uses thereof AUDAX PRIVATE DEBT LLC, AS AGENT 2004-10-28 US disclosed
US-6686461-B1 HYDRAZINO, OXYAMINO AND CARBONYL-BASED MONOMERS AND METHODS FOR LABELLING OF OLIGONUCLEOTIDES WITHOUT THE NEED FOR POST-SYNTHETIC MODIFICATION SOLULINK BIOSCIENCE, INC. 2004-02-03 US disclosed
EP-1305327-A2 TRIPHOSPHATE OLIGONUCLEOTIDE MODIFICATION REAGENTS AND USES THEREOF Schwartz, David A. (US) 2003-05-02 EP disclosed
WO-2002010432-A2 TRIPHOSPHATE OLIGONUCLEOTIDE MODIFICATION REAGENTS AND USES THEREOF SCHWARTZ DAVID A (US) 2002-02-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040214199-A1 Triphosphate oligonucleotide modification reagents and uses thereof RNGTT, DUT, NUDT1 FDPS 1899/4885BLM 1426/4885TDP1 374/4885
US-20070179288-A1 Triphosphate oligonucleotide modification reagents and uses thereof RNGTT, DUT, NUDT1 FDPS 1883/4885BLM 1350/4885TDP1 392/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.