⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22686137 | 0.68 | — | — | |
| SCHEMBL9264880 | 0.66 | CHRNB2 (0.32) | — | |
| SCHEMBL7858362 | 0.60 | — | — | |
| SCHEMBL9317948 | 0.59 | — | — | |
| SCHEMBL8810914 | 0.59 | CA12 (0.55) | — | |
| SCHEMBL21054186 | 0.58 | CA2 (0.31) | — | |
| SCHEMBL21054310 | 0.58 | — | — | |
| SCHEMBL4129020 | 0.57 | CA1 (0.58) | — | |
| SCHEMBL5907951 | 0.56 | CA12 (0.55) | — | |
| SCHEMBL5297954 | 0.56 | BRD4 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200369667-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | ANGEX PHARMACEUTICAL, INC. | 2020-11-26 | — | — | US | disclosed |
| CN-111741964-A | Heterocyclic compounds as PRMT5 inhibitors | 安杰斯制药公司 | 2020-10-02 | — | — | CN | disclosed |