Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL92282 | 0.74 | — | — | |
| SCHEMBL439923 | 0.74 | LMNA (0.33) | LMNACYP2C9 | |
| SCHEMBL14508121 | 0.71 | ALDH1A1 (0.31) | — | |
| SCHEMBL166075 | 0.70 | — | — | |
| SCHEMBL13129929 | 0.70 | — | — | |
| SCHEMBL12259718 | 0.70 | — | — | |
| SCHEMBL19027583 | 0.70 | — | — | |
| SCHEMBL13156976 | 0.70 | — | — | |
| SCHEMBL9607567 | 0.68 | TSHR (0.32) | LMNATSHRCYP2C9POLB | |
| SCHEMBL8070468 | 0.68 | LMNA (0.32) | LMNATSHRCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2515657-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |