Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 7/20 | 0.41 |
| ▸ | CDK8 | P49336 | 7/20 | 0.41 |
| ▸ | SCD | O00767 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22688972 | 1.00 | RIPK1 (0.44) | RIPK1SMN1; SMN2L3MBTL1CCNCCDK8 | |
| SCHEMBL22705446 | 0.93 | RIPK1 (0.47) | RIPK1SMN1; SMN2L3MBTL1CCNCCDK8 | |
| SCHEMBL22705508 | 0.91 | RIPK1 (0.56) | RIPK1SMN1; SMN2L3MBTL1SCDALDH1A1 | |
| SCHEMBL22705456 | 0.91 | L3MBTL1 (0.48) | RIPK1SMN1; SMN2L3MBTL1CCNCCDK8 | |
| SCHEMBL22705380 | 0.91 | RIPK1 (0.56) | RIPK1SMN1; SMN2L3MBTL1SCDALDH1A1 | |
| SCHEMBL22705453 | 0.90 | ROCK2 (0.43) | RIPK1SMN1; SMN2L3MBTL1CCNCCDK8 | |
| SCHEMBL22705379 | 0.90 | RIPK1 (0.43) | RIPK1SMN1; SMN2L3MBTL1CCNCCDK8 | |
| SCHEMBL22705385 | 0.90 | RIPK1 (0.43) | RIPK1SMN1; SMN2L3MBTL1CCNCCDK8 | |
| SCHEMBL22705359 | 0.90 | SCD (0.51) | RIPK1SMN1; SMN2L3MBTL1SCDROCK2 | |
| SCHEMBL24597770 | 0.89 | RIPK1 (0.42) | RIPK1SMN1; SMN2L3MBTL1CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111978311-B | Cell apoptosis inhibitor and preparation method and application thereof | 中国科学院上海有机化学研究所 | 2024-05-31 | — | — | CN | disclosed |
| US-20220213077-A1 | INHIBITORS FOR PROGRAMMED CELL NECROSIS AND PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2022-07-07 | — | — | US | disclosed |
| WO-2020233618-A1 | INHIBITORS FOR PROGRAMMED CELL NECROSIS AND PREPARATION METHOD THEREFOR AND USE THEREOF | 中国科学院上海有机化学研究所 (CN) | 2020-11-26 | — | — | WO | disclosed |
| WO-2020233618-A1 | INHIBITORS FOR PROGRAMMED CELL NECROSIS AND PREPARATION METHOD THEREFOR AND USE THEREOF | 中国科学院上海有机化学研究所 (CN) | 2020-11-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213077-A1 | INHIBITORS FOR PROGRAMMED CELL NECROSIS AND PREPARATION METHOD THEREFOR AND USE THEREOF | LITAF, TNF, BAD | RIPK1 146/4885SMN1; SMN2 3840/4885L3MBTL1 3153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.