Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 2/20 | 0.30 |
| ▸ | NOS1 | P29475 | 2/20 | 0.30 |
| ▸ | NOS2 | P35228 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19782447 | 0.86 | KCNH2 (0.33) | NUDT1ASIC3 | |
| SCHEMBL30041870 | 0.80 | KDM4E (0.33) | IRAK4 | |
| SCHEMBL1881803 | 0.80 | KDM4E (0.33) | IRAK4 | |
| SCHEMBL4857591 | 0.80 | MAPT (0.33) | IRAK4 | |
| SCHEMBL31574171 | 0.80 | NOS3 (0.33) | NOS3NOS1NOS2 | |
| SCHEMBL22689379 | 0.79 | KCNH2 (0.36) | — | |
| SCHEMBL30189795 | 0.78 | DUT (0.36) | NUDT1ASIC3 | |
| SCHEMBL2144122 | 0.78 | DUT (0.36) | NUDT1ASIC3 | |
| SCHEMBL25220483 | 0.78 | LOXL2 (0.39) | IRAK4NOS3NOS1NOS2 | |
| SCHEMBL17967618 | 0.77 | NOS3 (0.38) | SYKASIC3NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4347032-A1 | SUBSTITUTED TETRAHYDROFURAN-2-CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2024-04-10 | — | — | EP | disclosed |
| CN-117813302-A | Substituted tetrahydrofuran-2-carboxamides as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115916778-A | Methionine adenosyltransferase inhibitor, preparation method and application thereof | 赛诺哈勃药业（成都）有限公司 | 2023-04-04 | — | — | CN | disclosed |
| WO-2022256702-A1 | SUBSTITUTED TETRAHYDROFURAN-2-CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-12-08 | — | — | WO | disclosed |
| WO-2022256702-A1 | SUBSTITUTED TETRAHYDROFURAN-2-CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-12-08 | — | — | WO | disclosed |
| WO-2022053022-A1 | METHIONINE ADENOSYLTRANSFERASE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 赛诺哈勃药业（成都）有限公司 | 2022-03-17 | — | — | WO | disclosed |
| CN-114173825-A | Antibody-drug conjugates and their use in therapy | MCSAF公司 | 2022-03-11 | — | — | CN | disclosed |
| WO-2021064332-A1 | ANTI-CD30-DRUG CONJUGATES AND THEIR USE IN THERAPY | MC SAF (FR) | 2021-04-08 | — | — | WO | disclosed |
| WO-2020234541-A1 | ANTIBODY-DRUG CONJUGATES AND THEIR USE IN THERAPY | MC SAF (FR) | 2020-11-26 | — | — | WO | disclosed |