Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3616874 | 0.80 | ALDH1A1 (0.47) | ATMALDH1A1HPGDTSHRHCAR2 | |
| SCHEMBL3059935 | 0.77 | ALDH1A1 (0.44) | ATMALDH1A1HPGDTSHRHCAR2 | |
| SCHEMBL31269561 | 0.77 | ALDH1A1 (0.44) | ATMALDH1A1HPGDTSHRHCAR2 | |
| SCHEMBL1759122 | 0.77 | ALDH1A1 (0.44) | ATMALDH1A1HPGDTSHRHCAR2 | |
| SCHEMBL31269529 | 0.77 | ALDH1A1 (0.44) | ATMALDH1A1HPGDTSHRHCAR2 | |
| SCHEMBL8382644 | 0.76 | ALDH1A1 (0.42) | ATMALDH1A1HPGDTSHRHCAR2 | |
| SCHEMBL8382643 | 0.76 | ALDH1A1 (0.42) | ATMALDH1A1HPGDTSHRHCAR2 | |
| SCHEMBL8908299 | 0.76 | ALDH1A1 (0.50) | ATMALDH1A1HPGDTSHRHCAR2 | |
| SCHEMBL3434106 | 0.75 | ALDH1A1 (0.41) | ATMALDH1A1HPGDTSHRHCAR2 | |
| SCHEMBL28494423 | 0.75 | ALDH1A1 (0.41) | ATMALDH1A1HPGDTSHRHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983402-A1 | 1-((S)-1-(3-CHLORO-5-FLUORO-2-((4-(1H-PYRAZOL-1-YL)-2-METHYLQUINOLIN-8-YLOXY)METHYL)PHENYL)ETHYL)-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ (BK) B2 RECEPTOR ANTAGONIST FOR TREATING SKIN DISEASES | Pharvaris GmbH (CH) | 2022-04-20 | — | — | EP | disclosed |
| WO-2020234479-A1 | 1-((S)-1-(3-CHLORO-5-FLUORO-2-((4-(1H-PYRAZOL-1-YL)-2-METHYLQUINOLIN-8-YLOXY)METHYL)PHENYL)ETHYL)-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ (BK) B2 RECEPTOR ANTAGONIST FOR TREATING SKIN DISEASES | PHARVARIS GMBH (CH) | 2020-11-26 | — | — | WO | disclosed |