Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 16/20 | 0.56 |
| ▸ | OPRL1 | P41146 | 9/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.55 |
| ▸ | SCN1A | P35498 | 1/20 | 0.52 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.52 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 7/20 | 0.51 |
| ▸ | DRD2 | P14416 | 7/20 | 0.51 |
| ▸ | DRD4 | P21917 | 7/20 | 0.51 |
| ▸ | HTR1D | P28221 | 7/20 | 0.51 |
| ▸ | HTR2A | P28223 | 7/20 | 0.51 |
| ▸ | HTR2C | P28335 | 7/20 | 0.51 |
| ▸ | HTR7 | P34969 | 7/20 | 0.51 |
| ▸ | DRD1 | P21728 | 6/20 | 0.51 |
| ▸ | DRD5 | P21918 | 6/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.51 |
| ▸ | DRD3 | P35462 | 6/20 | 0.51 |
| ▸ | HTR2B | P41595 | 6/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9311212 | 0.93 | OPRM1 (0.52) | OPRM1OPRL1OPRD1OPRK1SCN1A | |
| SCHEMBL2273617 | 0.87 | OPRM1 (0.56) | OPRM1OPRL1OPRD1OPRK1SCN1A | |
| SCHEMBL9310673 | 0.87 | OPRM1 (0.49) | OPRM1OPRL1OPRD1OPRK1SCN1A | |
| SCHEMBL6796331 | 0.86 | MAPT (0.59) | OPRM1DRD2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3387476 | 0.83 | OPRM1 (0.61) | OPRM1OPRL1OPRD1OPRK1SCN1A | |
| SCHEMBL4815302 | 0.82 | OPRM1 (0.60) | OPRM1OPRL1OPRD1OPRK1SCN1A | |
| SCHEMBL14282297 | 0.81 | OPRM1 (0.58) | OPRM1OPRL1OPRD1OPRK1SCN1A | |
| SCHEMBL5235210 | 0.81 | L3MBTL1 (0.53) | OPRM1OPRL1OPRD1OPRK1DRD2 | |
| SCHEMBL3859039 | 0.81 | OPRM1 (0.70) | OPRM1OPRL1OPRD1OPRK1SCN1A | |
| SCHEMBL14282236 | 0.81 | OPRM1 (0.57) | OPRM1OPRL1OPRD1OPRK1SCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1714961-B1 | INDAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2015-12-09 | — | — | EP | disclosed |
| US-7994196-B2 | Indazole compound and pharmaceutical use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-08-09 | — | — | US | disclosed |
| US-20070173537-A1 | Indazole compound and pharmaceutical use thereof | MITSUBISHI PHARMA CORPORATION (JP) | 2007-07-26 | — | — | US | disclosed |
| EP-1714961-A1 | INDAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF | Mitsubishi Pharma Corporation (JP) | 2006-10-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173537-A1 | Indazole compound and pharmaceutical use thereof | CYP3A5, CYP3A43, TP53 | OPRM1 3770/4885OPRL1 3885/4885OPRD1 3666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.