Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 16/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 9/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.49 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 7/20 | 0.43 |
| ▸ | DRD2 | P14416 | 7/20 | 0.43 |
| ▸ | DRD4 | P21917 | 7/20 | 0.43 |
| ▸ | HTR1D | P28221 | 7/20 | 0.43 |
| ▸ | HTR2A | P28223 | 7/20 | 0.43 |
| ▸ | HTR2C | P28335 | 7/20 | 0.43 |
| ▸ | HTR7 | P34969 | 7/20 | 0.43 |
| ▸ | DRD1 | P21728 | 6/20 | 0.43 |
| ▸ | DRD5 | P21918 | 6/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.43 |
| ▸ | DRD3 | P35462 | 6/20 | 0.43 |
| ▸ | HTR2B | P41595 | 6/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9311212 | 0.94 | OPRM1 (0.52) | OPRM1OPRL1OPRD1OPRK1SCN1A | |
| SCHEMBL2269302 | 0.87 | OPRM1 (0.56) | OPRM1OPRL1OPRD1OPRK1SCN1A | |
| SCHEMBL5378396 | 0.85 | OPRM1 (0.52) | OPRM1OPRL1OPRD1OPRK1SCN1A | |
| SCHEMBL11020869 | 0.80 | OPRM1 (0.57) | OPRM1OPRL1OPRD1OPRK1SCN1A | |
| SCHEMBL9311661 | 0.79 | L3MBTL1 (0.50) | — | |
| SCHEMBL3984793 | 0.77 | CCR5 (0.44) | OPRM1OPRK1DRD2 | |
| SCHEMBL3984899 | 0.77 | OPRM1 (0.41) | OPRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1814122 | 0.75 | RORC (0.50) | OPRL1DRD2 | |
| SCHEMBL2273617 | 0.75 | OPRM1 (0.56) | OPRM1OPRL1OPRD1OPRK1SCN1A | |
| SCHEMBL3278197 | 0.74 | APP (0.53) | OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292738-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-08 | — | — | US | disclosed |
| US-5157035-A | Viricides | JANSSEN PHARMACEUTICA N. V. (BE) | 1992-10-20 | — | — | US | disclosed |
| US-5001125-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-03-19 | — | — | US | disclosed |
| EP-0156433-B1 | ANTI-VIRALLY ACTIVE PYRIDAZINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-02-27 | — | — | EP | disclosed |