Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2269302 | 0.86 | OPRM1 (0.56) | L3MBTL1OPRM1DRD2SLC6A2SLC6A4 | |
| SCHEMBL29995634 | 0.84 | NOS2 (0.54) | KMT2AMEN1 | |
| SCHEMBL29087312 | 0.84 | NOS2 (0.54) | KMT2AMEN1 | |
| SCHEMBL654359 | 0.83 | CCR5 (0.47) | DRD2KMT2AMEN1POLBTSHR | |
| SCHEMBL9311071 | 0.81 | OPRM1 (0.57) | MAPTHTTL3MBTL1OPRM1ALDH1A1 | |
| SCHEMBL3387438 | 0.80 | DRD2 (0.50) | OPRM1DRD2SLC6A3KMT2AMEN1 | |
| SCHEMBL9311212 | 0.79 | OPRM1 (0.52) | L3MBTL1OPRM1DRD2SLC6A2SLC6A4 | |
| SCHEMBL30702477 | 0.79 | NOS2 (0.52) | L3MBTL1OPRM1ALDH1A1APPKMT2A | |
| SCHEMBL9529108 | 0.78 | APP (0.59) | MAPTHTTL3MBTL1OPRM1ALDH1A1 | |
| SCHEMBL3852309 | 0.77 | DRD2 (0.54) | OPRM1DRD2ALDH1A1HPGDSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040044007-A1 | Indoline derivatives | H. LUNDBECK A/S (DK) | 2004-03-04 | — | — | US | disclosed |
| EP-1345921-A1 | 3-INDOLINE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC AND NEUROLOGIC DISORDERS | H. Lundbeck A/S (DK) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002051833-A1 | 3-INDOLINE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC AND NEUROLOGIC DISORDERS | H. LUNDBECK A/S (DK) | 2002-07-04 | — | — | WO | disclosed |
| EP-0861832-A1 | Novel tetrahydropyridine derivatives | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1998-09-02 | — | — | EP | disclosed |
| US-5410058-A | Exhibit high affinity and specificity to alpha receptors; useful in treating some psychoses | SHIONOGI & CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| US-5362873-A | Tetrahydropyridine derivatives | SHIONOGI & CO., LTD. (JP) | 1994-11-08 | — | — | US | disclosed |
| US-5243051-A | Treatment of psychological disorders | SHIONIGI & CO., LTD. (JP) | 1993-09-07 | — | — | US | disclosed |
| US-5149817-A | Psychotropic agents | SHIONOGI & CO., LTD. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445701-A1 | Novel tetrahydropyridine derivatives | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1991-09-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044007-A1 | Indoline derivatives | CNR1, GRIN2C, HTR3C | MAPT 1673/4885MAPK1 1122/4885HTT 345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.