Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 19/20 | 0.47 |
| ▸ | TNF | P01375 | 3/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22695045 | 0.88 | IL1B (0.61) | IL1BTNFNLRP3 | |
| SCHEMBL22695112 | 0.75 | IL1B (0.55) | IL1BTNFNLRP3 | |
| SCHEMBL22695168 | 0.74 | IL1B (0.47) | IL1BTNFNLRP3 | |
| SCHEMBL22655138 | 0.73 | IL1B (0.57) | IL1BTNFNLRP3 | |
| SCHEMBL22695042 | 0.73 | IL1B (0.57) | IL1BTNFNLRP3 | |
| SCHEMBL22671996 | 0.70 | IL1B (0.54) | IL1BTNFNLRP3 | |
| SCHEMBL18307332 | 0.70 | KDM4E (0.43) | RAPGEF4 | |
| SCHEMBL23364762 | 0.67 | MPL (0.53) | — | |
| SCHEMBL2084458 | 0.66 | AGBL2 (0.50) | — | |
| SCHEMBL31018138 | 0.66 | AGBL2 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020234715-A1 | NLRP3 INFLAMMASOME INHIBITORS | NOVARTIS AG (CH) | 2020-11-26 | — | — | WO | disclosed |