Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23254291 | 0.88 | KMT2A (0.57) | POLBKMT2ACYP2C9CYP2C19CYP1A2 | |
| SCHEMBL17520340 | 0.82 | SCD (0.56) | POLBKMT2AMAPK1CYP2C9CYP2C19 | |
| SCHEMBL14027975 | 0.80 | MEN1 (0.67) | POLBKMT2AL3MBTL1TDP1TP53 | |
| SCHEMBL23254586 | 0.77 | KMT2A (0.46) | POLBKMT2ACYP2C9CYP2C19CYP1A2 | |
| SCHEMBL6166972 | 0.76 | MEN1 (0.60) | POLBKMT2AL3MBTL1TDP1TP53 | |
| SCHEMBL5431925 | 0.76 | L3MBTL1 (0.57) | POLBKMT2AL3MBTL1TDP1CYP2C9 | |
| SCHEMBL14578666 | 0.75 | L3MBTL1 (0.89) | POLBKMT2AL3MBTL1TDP1MAPK1 | |
| SCHEMBL19212900 | 0.75 | ALDH1A1 (0.60) | KMT2ATP53CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL17979954 | 0.74 | DRD2 (0.70) | KMT2AL3MBTL1TDP1CYP2C19CYP1A2 | |
| SCHEMBL8723365 | 0.73 | TSHR (0.83) | POLBKMT2AL3MBTL1TDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177292-B1 | COMPOUNDS AND METHODS FOR TREATING CANCER | MAYO FOUND MEDICAL EDUCATION & RES (US) | 2020-11-25 | — | — | EP | disclosed |