Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | RAD52 | P43351 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | CASP7 | P55210 | 1/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.55 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166729 | 0.86 | POLB (0.66) | MEN1KMT2AALDH1A1POLBPTGDR2 | |
| SCHEMBL7316803 | 0.84 | FKBP1A (0.67) | MEN1KMT2AALDH1A1POLBL3MBTL1 | |
| SCHEMBL10586023 | 0.83 | TSHR (0.78) | MEN1KMT2AALDH1A1POLBL3MBTL1 | |
| SCHEMBL14027975 | 0.82 | MEN1 (0.67) | MEN1KMT2AALDH1A1POLBL3MBTL1 | |
| SCHEMBL5061551 | 0.79 | LMNA (0.56) | MEN1KMT2AALDH1A1POLBPTGDR2 | |
| SCHEMBL14578666 | 0.77 | L3MBTL1 (0.89) | MEN1KMT2AALDH1A1POLBL3MBTL1 | |
| SCHEMBL22697354 | 0.76 | POLB (0.59) | MEN1KMT2AALDH1A1POLBL3MBTL1 | |
| SCHEMBL8723365 | 0.75 | TSHR (0.83) | MEN1KMT2AALDH1A1POLBL3MBTL1 | |
| SCHEMBL21994956 | 0.75 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1RAD52POLB | |
| SCHEMBL1040183 | 0.75 | KMT2A (0.63) | MEN1KMT2AALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432686-B1 | TETRAHYDROISOCHINOLINES, THEIR PRODUCTION AND THE USE THEREOF AS ANALGESICS | BAYER HEALTHCARE AG (DE) | 2005-06-29 | — | — | EP | disclosed |
| US-20050049240-A1 | Tetrahydroisochinolines, their production and the use thereof as analgesics | BAYER HEALTHCARE AG (DE) | 2005-03-03 | — | — | US | disclosed |
| EP-1432686-A1 | TETRAHYDROISOCHINOLINES, THEIR PRODUCTION AND THE USE THEREOF AS ANALGESICS | Bayer HealthCare AG (DE) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003029221-A1 | TETRAHYDROISOCHINOLINES, THEIR PRODUCTION AND THE USE THEREOF AS ANALGESICS | BAYER HEALTHCARE AG (DE) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050049240-A1 | Tetrahydroisochinolines, their production and the use thereof as analgesics | OPRL1, OPRK1, TPMT | MEN1 1822/4885KMT2A 2328/4885ALDH1A1 1251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.