Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 16/20 | 0.34 |
| ▸ | JAK2 | O60674 | 8/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | QDPR | P09417 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2254487 | 0.85 | PDK4 (0.47) | JAK1 | |
| SCHEMBL2273140 | 0.74 | CDC7 (0.40) | — | |
| SCHEMBL2275585 | 0.73 | JAK1 (0.37) | JAK1JAK2 | |
| SCHEMBL23536398 | 0.72 | SHMT2 (0.35) | ATRQDPR | |
| SCHEMBL1937547 | 0.70 | GABRP (0.46) | MAPTQDPR | |
| SCHEMBL18186201 | 0.69 | MAPT (0.40) | LMNAMAPTQDPR | |
| SCHEMBL28945927 | 0.69 | JAK1 (0.39) | JAK1 | |
| SCHEMBL28996392 | 0.69 | MAPT (0.42) | USP2LMNAHPGDHTTMAPT | |
| SCHEMBL2273504 | 0.68 | JAK2 (0.46) | HPGDJAK2MAPT | |
| SCHEMBL16553643 | 0.68 | PDK4 (0.54) | JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8486967-B2 | Heteroaryl substituted piperidines | HOFFMANN-LA ROCHE INC. (US) | 2013-07-16 | — | — | US | disclosed |
| US-20110201605-A1 | HETEROARYL SUBSTITUTED PIPERIDINES | HOFFMANN-LA ROCHE, INC. | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201605-A1 | HETEROARYL SUBSTITUTED PIPERIDINES | APP, HPGDS, PSEN1 | USP2 1159/4885LMNA 453/4885HPGD 170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.