SCHEMBL22700489

SCHEMBL22700489

CCCC/N=C/c1c(O)c(O)c(C(C)C)c2c1C(=O)C(C1=C(C)C(=O)c3c(cc(O)c(O)c3C(C)C)C1=O)=C(C)C2=O

nearest known ligand 0.40

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
BCL2 P10415 8/20 0.40
MCL1 Q07820 8/20 0.40
GRK6 P43250 1/20 0.35
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
HSD17B10 Q99714 1/20 0.34
CNR2 P34972 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22700704 0.88 MCL1 (0.46) BCL2MCL1GRK6MEN1KMT2A
SCHEMBL22700390 0.85 MCL1 (0.50) BCL2MCL1MEN1KMT2A
SCHEMBL22700775 0.83 MAOA (0.36) BCL2MCL1MEN1KMT2AHSD17B10
SCHEMBL22686504 0.81 ALB (0.42) BCL2MCL1MEN1KMT2AHSD17B10
SCHEMBL22700400 0.80 MAPT (0.36) BCL2MCL1MEN1KMT2A
SCHEMBL22700765 0.78 SMN1; SMN2 (0.32) KMT2A
SCHEMBL22700774 0.78 CNR2 (0.34) HSD17B10CNR2
SCHEMBL22700720 0.77 MAPT (0.42) BCL2MCL1MEN1KMT2A
SCHEMBL1890983 0.77 EGFR (0.42) BCL2MCL1MEN1KMT2AHSD17B10
SCHEMBL22700398 0.75 MEN1 (0.35) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200369618-A1 ASYMMETRIC DERIVATIVES OF POLYPHENOLS OF THE DINAPHTHALINE SERIES, PROCESS OF PREPARING AND USE THEREOF Nearmedic International Limited (CY) 2020-11-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200369618-A1 ASYMMETRIC DERIVATIVES OF POLYPHENOLS OF THE DINAPHTHALINE SERIES, PROCESS OF PREPARING AND USE THEREOF DNM2, DNM1, MAVS BCL2 3675/4885MCL1 3671/4885GRK6 3081/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.