Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.40 |
| ▸ | CACNG8 | Q8WXS5 | 4/20 | 0.40 |
| ▸ | CCKBR | P32239 | 3/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11964631 | 0.84 | CCKBR (0.58) | CCKBRLMNAMEN1KMT2AALB | |
| SCHEMBL2262529 | 0.84 | CCKBR (0.58) | CCKBRLMNAMEN1KMT2AALB | |
| SCHEMBL2267642 | 0.83 | LMNA (0.44) | CCKBRLMNAMEN1KMT2AALB | |
| SCHEMBL14707309 | 0.82 | CCKBR (0.47) | CCKBRLMNAMEN1KMT2AALB | |
| SCHEMBL2796264 | 0.80 | TAAR1 (0.38) | CCKBRLMNAMEN1KMT2AALB | |
| SCHEMBL2797615 | 0.78 | CHRM1 (0.40) | CCKBRLMNAMEN1KMT2AALB | |
| SCHEMBL2268179 | 0.76 | OPRK1 (0.48) | DYRK1AGRIA1CACNG8CCKBRLMNA | |
| SCHEMBL13061033 | 0.75 | CCKBR (0.47) | DYRK1AGRIA1CACNG8CCKBRLMNA | |
| SCHEMBL1515218 | 0.75 | CCKBR (0.47) | DYRK1AGRIA1CACNG8CCKBR | |
| SCHEMBL11964634 | 0.75 | CCKBR (0.56) | CCKBRLMNAMEN1KMT2AALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120289498-A1 | Compositions And Methods Relating To Novel Compounds And Targets Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-11-15 | — | — | US | disclosed |
| US-8242109-B2 | Compositions and methods relating to novel compounds and targets thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-08-14 | — | — | US | disclosed |
| US-20110195959-A1 | Compositions And Methods Relating To Novel Compounds And Targets Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-08-11 | — | — | US | disclosed |
| US-7851465-B2 | Compositions and methods relating to novel compounds and targets thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110195959-A1 | Compositions And Methods Relating To Novel Compounds And Targets Thereof | BAX, BAD, BAK1 | DYRK1A 3166/4885GRIA1 207/4885CACNG8 536/4885 |
| US-20120289498-A1 | Compositions And Methods Relating To Novel Compounds And Targets Thereof | BAX, BAD, BAK1 | DYRK1A 3166/4885GRIA1 207/4885CACNG8 536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.