Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22707664 | 1.00 | LMNA (0.39) | LMNAMETAP2ALDH1A1CAPN1EPHX2 | |
| SCHEMBL22708096 | 0.88 | ABCB1 (0.39) | METAP2ALDH1A1EPHX2TSHRKMT2A | |
| SCHEMBL16575274 | 0.81 | LMNA (0.40) | LMNAMETAP2ALDH1A1CAPN1CYP2C9 | |
| SCHEMBL10158830 | 0.81 | LMNA (0.40) | LMNAMETAP2ALDH1A1CAPN1CYP2C9 | |
| SCHEMBL13976546 | 0.80 | ALDH1A1 (0.41) | LMNAMETAP2ALDH1A1CAPN1TSHR | |
| SCHEMBL15935496 | 0.80 | ALDH1A1 (0.41) | LMNAMETAP2ALDH1A1CAPN1TSHR | |
| SCHEMBL14946301 | 0.80 | ALDH1A1 (0.41) | LMNAMETAP2ALDH1A1CAPN1TSHR | |
| SCHEMBL9961266 | 0.80 | ALDH1A1 (0.41) | LMNAMETAP2ALDH1A1CAPN1TSHR | |
| SCHEMBL20960060 | 0.79 | ALDH1A1 (0.43) | LMNAMETAP2ALDH1A1CAPN1TSHR | |
| SCHEMBL24672951 | 0.79 | BCHE (0.43) | METAP2ALDH1A1EPHX2TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303612-A1 | Novel Spirobicyclic Analogues | JANSSEN PHARMACEUTICA NV (BE) | 2023-09-28 | — | — | US | disclosed |
| US-11702441-B2 | Spirobicyclic analogues | JANSSEN PHARMACEUTICA NV (BE) | 2023-07-18 | — | — | US | disclosed |
| US-20220275018-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | JANSSEN PHARMACEUTICA NV (BE) | 2022-09-01 | — | — | US | disclosed |
| US-20210380627-A1 | Novel Spirobicyclic Analogues | JANSSEN PHARMACEUTICA NV (BE) | 2021-12-09 | — | — | US | disclosed |
| US-11059850-B2 | Spirobicyclic analogues | JANSSEN PHARMACEUTICA NV (BE) | 2021-07-13 | — | — | US | disclosed |
| US-20200369707-A1 | NOVEL SPIROBICYCLIC ANALOGUES | VRIJE UNIVERSITEIT BRUSSEL (BE) | 2020-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200369707-A1 | NOVEL SPIROBICYCLIC ANALOGUES | PRMT5, SIRT5, HDAC5 | LMNA 1300/4885METAP2 3331/4885ALDH1A1 1379/4885 |
| US-20210380627-A1 | Novel Spirobicyclic Analogues | PRMT5, SIRT5, HDAC5 | LMNA 1300/4885METAP2 3331/4885ALDH1A1 1379/4885 |
| US-20220275018-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | NME2, SLC28A1, SLC28A2 | LMNA 742/4885METAP2 2682/4885ALDH1A1 248/4885 |
| US-20230303612-A1 | Novel Spirobicyclic Analogues | PRMT5, SIRT5, HDAC5 | LMNA 1300/4885METAP2 3331/4885ALDH1A1 1379/4885 |
| US-11059850-B2 | Spirobicyclic analogues | PRMT5, HDAC5, SIRT5 | LMNA 961/4885METAP2 3510/4885ALDH1A1 1492/4885 |
| US-11702441-B2 | Spirobicyclic analogues | PRMT5, HDAC5, SIRT5 | LMNA 961/4885METAP2 3510/4885ALDH1A1 1492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.