SCHEMBL22714367

SCHEMBL22714367

O=[N+]([O-])c1cc(C=NO)c(Cl)cc1Cl

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 7/20 0.49
KMT2A Q03164 7/20 0.49
MAPT P10636 7/20 0.49
ALDH1A1 P00352 6/20 0.49
HPGD P15428 2/20 0.49
KDM4E B2RXH2 1/20 0.49
POLB P06746 1/20 0.49
CYP3A4 P08684 1/20 0.49
L3MBTL1 Q9Y468 3/20 0.44
MAPK1 P28482 3/20 0.44
HSP90AA1 P07900 1/20 0.44
TSHR P16473 1/20 0.42
VCAM1 P19320 2/20 0.41
HTT P42858 3/20 0.39
LMNA P02545 2/20 0.39
TDP1 Q9NUW8 1/20 0.39
GPR35 Q9HC97 1/20 0.39
F2 P00734 1/20 0.38
PRSS1 P07477 1/20 0.38
PRSS2 P07478 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22714365 1.00 MEN1 (0.49) MEN1KMT2AMAPTALDH1A1HPGD
SCHEMBL21635537 0.85 MEN1 (0.41) MEN1KMT2AMAPTALDH1A1HPGD
SCHEMBL21635536 0.85 MEN1 (0.41) MEN1KMT2AMAPTALDH1A1HPGD
SCHEMBL31580282 0.85 MEN1 (0.41) MEN1KMT2AMAPTALDH1A1HPGD
SCHEMBL21635538 0.85 MEN1 (0.41) MEN1KMT2AMAPTALDH1A1HPGD
SCHEMBL22288797 0.82 MEN1 (0.43) MEN1KMT2AMAPTALDH1A1HPGD
SCHEMBL22288798 0.82 MEN1 (0.43) MEN1KMT2AMAPTALDH1A1HPGD
SCHEMBL7172758 0.79 MAPT (0.46) MEN1KMT2AMAPTALDH1A1HPGD
SCHEMBL7159857 0.79 MAPT (0.46) MEN1KMT2AMAPTALDH1A1HPGD
SCHEMBL537580 0.78 VCAM1 (0.55) MEN1KMT2AMAPTALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12202821-B2 Herbicidal compounds SYNGENTA CROP PROTECTION AG (CH) 2025-01-21 US disclosed
CN-118084888-A Herbicidal compounds 先正达农作物保护股份公司 2024-05-28 CN disclosed
CN-113874368-B Herbicidal compounds 先正达农作物保护股份公司 2024-03-08 CN disclosed
EP-3976603-B1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2023-11-15 EP disclosed
US-20220227744-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-07-21 US disclosed
EP-3976603-A1 HERBICIDAL COMPOUNDS Syngenta Crop Protection AG (CH) 2022-04-06 EP disclosed
CN-113874368-A Herbicidal compounds 先正达农作物保护股份公司 2021-12-31 CN disclosed
WO-2020239607-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-12-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220227744-A1 HERBICIDAL COMPOUNDS DDT, ACHE, GSTO1 MEN1 3365/4885KMT2A 1038/4885MAPT 4021/4885
US-12202821-B2 Herbicidal compounds DDT, ACHE, GSTO1 MEN1 3365/4885KMT2A 1038/4885MAPT 4021/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.