Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29704120 | 1.00 | LRRK2 (0.40) | LRRK2CYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL22635577 | 0.87 | CYP2C9 (0.43) | LRRK2CYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL18378721 | 0.77 | CYP2C19 (0.44) | LRRK2CYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL31565756 | 0.76 | LMNA (0.46) | CYP2C9CYP2C19CA1CA2CA9 | |
| SCHEMBL17194995 | 0.75 | LRRK2 (0.40) | LRRK2CYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL9959654 | 0.72 | STAT3 (0.42) | LRRK2HCRTR1HCRTR2CA1CA2 | |
| SCHEMBL29704124 | 0.72 | CA2 (0.51) | LRRK2CYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL31331822 | 0.72 | PIK3CD (0.43) | LRRK2CYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL28732947 | 0.71 | BRD4 (0.53) | CYP2E1CYP2A6CYP2C9CYP2B6CYP2C19 | |
| SCHEMBL29602351 | 0.71 | BRD4 (0.53) | CYP2E1CYP2A6CYP2C9CYP2B6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976194-A2 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |
| WO-2020243415-A2 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2020-12-03 | — | — | WO | disclosed |