Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.51 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.47 |
| ▸ | MPO | P05164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.45 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.45 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31331710 | 0.78 | MAPT (0.49) | LMNAPOLBRXFP1AKR1C3AKR1C2 | |
| SCHEMBL22718422 | 0.78 | MAPT (0.49) | LMNAPOLBRXFP1AKR1C3AKR1C2 | |
| SCHEMBL5196436 | 0.74 | NPC1 (0.56) | RXFP1HTTMCHR1MAPT | |
| SCHEMBL22719798 | 0.72 | RAPGEF4 (0.57) | LMNAPOLBRXFP1AKR1C3AKR1C2 | |
| SCHEMBL11086700 | 0.72 | RAPGEF4 (0.56) | LMNARXFP1AKR1C3AKR1C2RAPGEF4 | |
| SCHEMBL22025431 | 0.71 | RXFP1 (0.67) | LMNAPOLBRXFP1SMN1; SMN2MAPT | |
| SCHEMBL28665402 | 0.70 | RXFP1 (0.80) | RXFP1 | |
| SCHEMBL5491795 | 0.70 | RXFP1 (0.88) | POLBRXFP1MAPT | |
| SCHEMBL30291135 | 0.70 | PLK1 (0.51) | POLB | |
| SCHEMBL15529016 | 0.70 | RXFP1 (1.00) | RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976192-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |
| WO-2020243423-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2020-12-03 | — | — | WO | disclosed |