Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 4/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1503250 | 0.91 | MMP1 (0.39) | ALDH1A1GAAMAOBEGLN1KMT2A | |
| SCHEMBL30954811 | 0.91 | MMP1 (0.39) | ALDH1A1GAAMAOBEGLN1KMT2A | |
| SCHEMBL1503187 | 0.87 | ALDH1A1 (0.41) | ALDH1A1GAAMAOBKMT2AMEN1 | |
| SCHEMBL22738236 | 0.87 | EGLN1 (0.39) | ALDH1A1EGLN1KMT2AMEN1 | |
| SCHEMBL22738288 | 0.86 | GABRA5 (0.42) | ALDH1A1GAAEGLN1KMT2AMEN1 | |
| SCHEMBL15746710 | 0.85 | NR4A2 (0.45) | ALDH1A1GAAMAOBEGLN1MMP1 | |
| SCHEMBL22738223 | 0.85 | SCN9A (0.41) | MAOBEGLN1MAOA | |
| SCHEMBL22738229 | 0.84 | LMNA (0.50) | EGLN1 | |
| SCHEMBL22719956 | 0.84 | ALDH1A1 (0.38) | ALDH1A1GAAMAOBKMT2AMEN1 | |
| SCHEMBL22738219 | 0.83 | EGLN1 (0.41) | EGLN1KMT2AMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |