SCHEMBL22722975

SCHEMBL22722975

Nc1ccc(-c2ccc(N)cc2CF)c(CF)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.43
GAA P10253 3/20 0.43
POLB P06746 2/20 0.43
GLA P06280 1/20 0.43
PRKCI P41743 1/20 0.41
ACHE P22303 3/20 0.39
ALDH1A1 P00352 5/20 0.37
CYP3A4 P08684 4/20 0.37
NPC1 O15118 3/20 0.37
RAB9A P51151 3/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
MAPK1 P28482 2/20 0.37
TP53 P04637 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
LMNA P02545 3/20 0.35
PTPRC P08575 2/20 0.35
HPGD P15428 2/20 0.35
HTT P42858 2/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21247623 0.87 CYP3A4 (0.40) TSHRGAAPOLBGLAPRKCI
SCHEMBL17987614 0.84 GAA (0.71) TSHRGAAPOLBGLAPRKCI
SCHEMBL31303603 0.81 PRKCI (0.62) TSHRGAAPOLBPRKCIACHE
SCHEMBL28578528 0.80 CASP1 (0.37) TSHRGAAPOLBGLAPRKCI
SCHEMBL12844067 0.78 TAAR1 (0.38) TSHRGAAPOLBGLAPRKCI
SCHEMBL10034977 0.76 ALDH1A1 (0.52) TSHRGAAPRKCIACHEALDH1A1
SCHEMBL13898460 0.76 TAAR1 (0.35) TSHRGAAPOLBGLAPRKCI
SCHEMBL2665541 0.76 CYP3A4 (0.52) TSHRGAAPOLBPRKCIALDH1A1
SCHEMBL7544401 0.76 TSHR (0.50) TSHRGAAPOLBGLAPRKCI
SCHEMBL19069785 0.76 MAPT (0.37) TSHRGAAPOLBGLAPRKCI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10858482-B2 Composition of preparing poly(imide-benzoxazole) copolymer, poly(imide-benzoxazole) copolymer, article containing poly(imide-benzoxazole) copolymer, and display device including same SAMSUNG ELECTRONICS CO., LTD. (KR) 2020-12-08 US claimed
CN-111423582-B Polyimide resin for positive photoresist and preparation method thereof 上海极紫科技有限公司 2023-04-18 CN disclosed
CN-111333837-B Positive photosensitive polyimide resin and preparation method thereof 上海极紫科技有限公司 2022-11-25 CN disclosed