Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 9/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 5/20 | 0.33 |
| ▸ | DRD2 | P14416 | 4/20 | 0.33 |
| ▸ | CFD | P00746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4208861 | 0.80 | RAB9A (0.43) | HTTADORA2AADORA1 | |
| SCHEMBL21238765 | 0.77 | — | — | |
| SCHEMBL15971596 | 0.76 | ADORA2A (0.40) | ADORA2AADORA1 | |
| SCHEMBL12873382 | 0.69 | NAPRT (0.38) | — | |
| SCHEMBL1483734 | 0.69 | ADORA2A (0.38) | ICMTHTTADORA2AADORA1 | |
| SCHEMBL30006395 | 0.69 | ICMT (0.39) | ICMTADORA2AADORA1 | |
| SCHEMBL22723977 | 0.68 | ICMT (0.35) | ICMTHTTDRD3DRD2CFD | |
| SCHEMBL30056108 | 0.68 | ATM (0.39) | HTTADORA2AADORA1 | |
| SCHEMBL29159245 | 0.67 | MAOA (0.41) | HTT | |
| SCHEMBL345169 | 0.64 | ADORA2A (0.37) | ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3744721-A1 | CONDENSED CYCLIC COMPOUND HAVING DOPAMINE D3 RECEPTOR ANTAGONISM | Shionogi & Co., Ltd (JP) | 2020-12-02 | — | — | EP | disclosed |