Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.34 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3354284 | 0.84 | TAAR1 (0.45) | LMNAKDM4ERIPK1LOXL2DPP4 | |
| SCHEMBL22728284 | 0.81 | IDO1 (0.32) | IDO1 | |
| SCHEMBL3354281 | 0.81 | KDM4E (0.37) | KDM4ERIPK1DPP4 | |
| SCHEMBL22728363 | 0.80 | RIPK1 (0.40) | ESR1ESR2RIPK1MAOAMAOB | |
| SCHEMBL3354278 | 0.80 | TAAR1 (0.34) | LMNAKDM4ERIPK1DPP4TAAR1 | |
| SCHEMBL14446924 | 0.79 | KDM4E (0.39) | LMNAKDM4EESR1ESR2RIPK1 | |
| SCHEMBL3160096 | 0.76 | ESR1 (0.42) | LMNAKDM4EESR1ESR2IDO1 | |
| SCHEMBL22728387 | 0.75 | TRPA1 (0.35) | LMNAKDM4EESR1ESR2RIPK1 | |
| SCHEMBL22728319 | 0.75 | TRPA1 (0.35) | LMNAKDM4EESR1ESR2RIPK1 | |
| SCHEMBL22728334 | 0.75 | RIPK1 (0.41) | KDM4ERIPK1IDO1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243027-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | SAGE THERAPEUTICS, INC. (US) | 2020-12-03 | — | — | WO | disclosed |