Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | AGXT | P21549 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22728339 | 0.83 | IDO1 (0.46) | IDO1SLC6A2SLC6A4 | |
| SCHEMBL22728326 | 0.83 | IDO1 (0.45) | IDO1HTR2ADAOSLC6A2SLC6A4 | |
| SCHEMBL31118083 | 0.82 | RIPK1 (0.40) | RIPK1IDO1AGXTKDM4ESMN1; SMN2 | |
| SCHEMBL22728386 | 0.79 | OPRL1 (0.36) | SLC6A2SLC6A4 | |
| SCHEMBL22728287 | 0.77 | RIPK1 (0.37) | RIPK1 | |
| SCHEMBL22728367 | 0.75 | TAAR1 (0.33) | RIPK1HTR2AHTR2CSLC6A4 | |
| SCHEMBL13548281 | 0.75 | RIPK1 (0.49) | RIPK1IDO1AGXTKDM4ESMN1; SMN2 | |
| SCHEMBL22728291 | 0.75 | LMNA (0.37) | RIPK1IDO1KDM4EMAOB | |
| SCHEMBL22728302 | 0.73 | RIPK1 (0.41) | RIPK1 | |
| SCHEMBL22728332 | 0.73 | IDO1 (0.45) | IDO1HTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243027-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | SAGE THERAPEUTICS, INC. (US) | 2020-12-03 | — | — | WO | disclosed |