Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | MIF | P14174 | 2/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ACP3 | P15309 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22728398 | 0.78 | PNMT (0.43) | TAAR1IDO1ATMKDM4EKMT2A | |
| SCHEMBL24064919 | 0.77 | TAAR1 (0.56) | HTR2AHTR2BHTR2CTAAR1MAPT | |
| SCHEMBL12881790 | 0.77 | HTR2A (0.53) | HTR2AHTR2BHTR2CTAAR1MAPT | |
| SCHEMBL46757 | 0.75 | HTR2A (0.63) | HTR2AHTR2BHTR2CTAAR1MAPT | |
| SCHEMBL73993 | 0.74 | HTR2A (0.58) | HTR2AHTR2BHTR2CTAAR1MAPT | |
| SCHEMBL429769 | 0.74 | TAAR1 (0.67) | HTR2AHTR2BHTR2CTAAR1MAPT | |
| SCHEMBL30876859 | 0.74 | TAAR1 (0.67) | HTR2AHTR2BHTR2CTAAR1MAPT | |
| SCHEMBL22728332 | 0.74 | IDO1 (0.45) | HTR2ASLC6A4IDO1CTSSCTSK | |
| SCHEMBL22728326 | 0.74 | IDO1 (0.45) | HTR2ASLC6A4IDO1GAACTSS | |
| SCHEMBL4656626 | 0.74 | TAAR1 (0.45) | HTR2AHTR2BHTR2CTAAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243027-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | SAGE THERAPEUTICS, INC. (US) | 2020-12-03 | — | — | WO | disclosed |