Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.41 |
| ▸ | HTR3B | O95264 | 2/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.41 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | AGXT | P21549 | 2/20 | 0.40 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22728328 | 0.78 | HTR2A (0.47) | TAAR1KDM4EATMIDO1KMT2A | |
| SCHEMBL11974009 | 0.75 | RIPK1 (0.49) | PNMTRIPK1TAAR1HTR3EHTR3B | |
| SCHEMBL22728363 | 0.75 | RIPK1 (0.40) | RIPK1ATM | |
| SCHEMBL22728320 | 0.73 | CYP1A2 (0.52) | ATMPYCR1 | |
| SCHEMBL7109269 | 0.73 | PNMT (0.50) | PNMTRIPK1TAAR1HTR3EHTR3B | |
| SCHEMBL73643 | 0.72 | PNMT (0.54) | PNMTRIPK1TAAR1HTR3EHTR3B | |
| SCHEMBL4656370 | 0.72 | PNMT (0.42) | PNMTTAAR1HTR3EHTR3BHTR3A | |
| SCHEMBL5927681 | 0.72 | ATM (0.46) | PNMTTAAR1HTR3EHTR3BHTR3A | |
| SCHEMBL22728365 | 0.72 | SLC6A4 (0.37) | TAAR1KDM4ECYP3A4IDO1KMT2A | |
| SCHEMBL6821416 | 0.71 | PNMT (0.41) | PNMTTAAR1HTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243027-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | SAGE THERAPEUTICS, INC. (US) | 2020-12-03 | — | — | WO | disclosed |