Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 2/20 | 0.32 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22728326 | 0.88 | IDO1 (0.45) | IDO1USP30PDE2AARCETP | |
| SCHEMBL22728367 | 0.81 | TAAR1 (0.33) | ARHTR2ASLC6A4 | |
| SCHEMBL13021064 | 0.75 | IDO1 (0.54) | IDO1USP30PDE2AHTR2ASLC6A4 | |
| SCHEMBL8189407 | 0.75 | IDO1 (0.58) | IDO1USP30PDE2ACETPCA1 | |
| SCHEMBL22728328 | 0.74 | HTR2A (0.47) | IDO1HTR2ASLC6A4CTSSCTSK | |
| SCHEMBL952712 | 0.74 | IDO1 (0.53) | IDO1USP30PDE2APTGDR2HTR2A | |
| SCHEMBL29492592 | 0.74 | IDO1 (0.53) | IDO1USP30PDE2APTGDR2HTR2A | |
| SCHEMBL22728334 | 0.73 | RIPK1 (0.41) | IDO1HTR2ASLC6A4 | |
| SCHEMBL22728339 | 0.73 | IDO1 (0.46) | IDO1SLC6A4P2RX7 | |
| SCHEMBL22728383 | 0.73 | CTSS (0.42) | ARCTSSCTSKP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243027-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | SAGE THERAPEUTICS, INC. (US) | 2020-12-03 | — | — | WO | disclosed |