Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.30 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.30 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.30 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22728332 | 0.81 | IDO1 (0.45) | SLC6A4HTR2AAR | |
| SCHEMBL22728334 | 0.75 | RIPK1 (0.41) | HTR2CSLC6A4HTR2ARIPK1 | |
| SCHEMBL22728363 | 0.73 | RIPK1 (0.40) | RIPK1 | |
| SCHEMBL765891 | 0.73 | TAAR1 (0.39) | TAAR1MAPK1MAP2K4MAPKAPK2MAPKAPK3 | |
| SCHEMBL12828079 | 0.73 | TAAR1 (0.39) | TAAR1MAPK1MAP2K4MAPKAPK2MAPKAPK3 | |
| SCHEMBL22728302 | 0.72 | RIPK1 (0.41) | RIPK1 | |
| SCHEMBL22728326 | 0.72 | IDO1 (0.45) | SLC6A4HTR2AAR | |
| SCHEMBL952178 | 0.72 | TAAR1 (0.38) | TAAR1HTR2CSLC6A4MAPK1MAP2K4 | |
| SCHEMBL8239069 | 0.70 | TAAR1 (0.43) | TAAR1MAPK1MAP2K4MAPKAPK2MAPKAPK3 | |
| SCHEMBL22728287 | 0.69 | RIPK1 (0.37) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243027-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | SAGE THERAPEUTICS, INC. (US) | 2020-12-03 | — | — | WO | disclosed |