Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 4/20 | 0.32 |
| ▸ | NOS1 | P29475 | 4/20 | 0.32 |
| ▸ | NOS2 | P35228 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22728312 | 0.83 | PYCR1 (0.42) | SLC6A4HTR2AKCNH2GGPS1SLC6A2 | |
| SCHEMBL22728309 | 0.78 | KDM4C (0.35) | NOS3NOS1NOS2TAAR1MEN1 | |
| SCHEMBL3782085 | 0.74 | IDO1 (0.44) | SLC6A4HTR2AKCNH2FLT1FLT4 | |
| SCHEMBL22728398 | 0.72 | PNMT (0.43) | KDM4EIDO1TAAR1CYP3A4KMT2A | |
| SCHEMBL22728334 | 0.69 | RIPK1 (0.41) | SLC6A4HTR2ASLC6A2KDM4EIDO1 | |
| SCHEMBL30102510 | 0.68 | HTR2A (0.51) | SLC6A4HTR2AKCNH2FLT1FLT4 | |
| SCHEMBL257058 | 0.68 | HTR2A (0.51) | SLC6A4HTR2AKCNH2FLT1FLT4 | |
| SCHEMBL14115702 | 0.68 | NOS2 (0.51) | NOS3NOS1NOS2KDM4EMAPT | |
| SCHEMBL19304439 | 0.68 | VCAM1 (0.44) | SLC6A4HTR2AKCNH2SLC6A2JAK2 | |
| SCHEMBL22728367 | 0.68 | TAAR1 (0.33) | SLC6A4HTR2AMAPK1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243027-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | SAGE THERAPEUTICS, INC. (US) | 2020-12-03 | — | — | WO | disclosed |