Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19660155 | 0.86 | HDAC8 (0.50) | ALOX15ALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL19660002 | 0.83 | ALOX15 (0.51) | ALOX15GFERADAM17RAB9AALDH1A1 | |
| SCHEMBL22728769 | 0.83 | HDAC3 (0.44) | RAB9AALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL23797050 | 0.82 | ALOX15 (0.50) | ALOX15GFERADAM17RAB9AALDH1A1 | |
| SCHEMBL23797019 | 0.81 | L3MBTL1 (0.55) | RAB9AALDH1A1PKMHTTKDM4E | |
| SCHEMBL10455298 | 0.76 | HDAC3 (0.54) | ALOX15GFERADAM17RAB9AALDH1A1 | |
| SCHEMBL23617221 | 0.74 | ALOX15 (0.54) | ALOX15GFERADAM17RAB9AALDH1A1 | |
| SCHEMBL19642631 | 0.73 | ATM (0.54) | ALOX15GFERADAM17RAB9AALDH1A1 | |
| SCHEMBL10883891 | 0.73 | HDAC3 (0.60) | ALOX15GFERADAM17RAB9AALDH1A1 | |
| SCHEMBL20487435 | 0.73 | ALOX15 (0.53) | ALOX15GFERADAM17RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3580211-B1 | 2-HETEROARYL-3-OXO-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES FOR THE TREATMENT OF CANCER | BAYER AG (DE) | 2020-12-02 | — | — | EP | disclosed |