Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | FADS1 | O60427 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 5/20 | 0.36 |
| ▸ | MAOA | P21397 | 3/20 | 0.34 |
| ▸ | MAOB | P27338 | 3/20 | 0.34 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16488517 | 0.73 | HTR2C (0.43) | HTR2CFADS1TRPA1CNR2DRD1 | |
| SCHEMBL557772 | 0.73 | NOS3 (0.43) | HTR2CFADS1TRPA1CNR2DRD1 | |
| SCHEMBL22323315 | 0.73 | TRPA1 (0.46) | HTR2CFADS1TRPA1CNR2DRD1 | |
| SCHEMBL11625851 | 0.73 | HTR2C (0.43) | HTR2CFADS1TRPA1CNR2DRD1 | |
| SCHEMBL127374 | 0.73 | FADS1 (0.46) | HTR2CFADS1TRPA1CNR2DRD1 | |
| SCHEMBL29615409 | 0.73 | FADS1 (0.46) | HTR2CFADS1TRPA1CNR2DRD1 | |
| SCHEMBL2757287 | 0.73 | HTR2C (0.47) | HTR2CFADS1TRPA1PDE3BPDE3A | |
| SCHEMBL15688333 | 0.73 | HTR2C (0.43) | HTR2CFADS1TRPA1CNR2DRD1 | |
| SCHEMBL15688342 | 0.69 | MAPT (0.38) | HTR2CFADS1TRPA1CNR2MAOA | |
| SCHEMBL4429415 | 0.68 | PAX8 (0.48) | HTR2CMAOAMAOBFTONFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3535269-B1 | [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS PDE2 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-09 | — | — | EP | disclosed |