Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 7/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.37 |
| ▸ | PDE5A | O76074 | 6/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4221778 | 0.93 | PRKCA (0.54) | PRKCAMMP12CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2273051 | 0.92 | PRKCA (0.48) | PRKCAMMP12PDE4APDE4BPDE4C | |
| SCHEMBL4210043 | 0.85 | PRKCA (0.54) | PRKCAMMP12CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL395908 | 0.84 | PRKCA (0.59) | PRKCAMMP12CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2276283 | 0.84 | PRKCA (0.55) | PRKCAMMP12PDE4APDE4BPDE4C | |
| SCHEMBL2276966 | 0.84 | PRKCA (0.46) | PRKCAMMP12CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2278178 | 0.81 | PRKCA (0.48) | PRKCAMMP12CYP3A4KCNH2NR1I2 | |
| SCHEMBL4215913 | 0.79 | PRKCA (0.51) | PRKCAMMP12CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL792698 | 0.78 | MET (0.38) | PRKCAMMP12CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL772494 | 0.78 | PRKCA (0.45) | PRKCAMMP12CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989438-B2 | Therapeutic compounds | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-08-02 | — | — | US | disclosed |