SCHEMBL2272995

SCHEMBL2272995

CN[SiH](c1ccccc1)C(C)(C)C

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 1/20 0.36
CYP2D6 P10635 2/20 0.35
LMNA P02545 1/20 0.35
TSHR P16473 2/20 0.35
CHRM2 P08172 2/20 0.31
ADRA1A P35348 2/20 0.31
CACNA1F O60840 1/20 0.31
CHRM1 P11229 1/20 0.31
ADRA2B P18089 1/20 0.31
CHRM3 P20309 1/20 0.31
HRH1 P35367 1/20 0.31
OPRK1 P41145 1/20 0.31
CACNA1D Q01668 1/20 0.31
SLC6A3 Q01959 1/20 0.31
KCNH2 Q12809 1/20 0.31
CACNA1S Q13698 1/20 0.31
CACNA1C Q13936 1/20 0.31
SCN5A Q14524 1/20 0.31
MAPK1 P28482 1/20 0.31
CYP3A4 P08684 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20218966 0.79 ATM (0.31) KCNN4CYP2D6LMNACHRM2ADRA1A
SCHEMBL2268944 0.76 KCNN4 (0.38) KCNN4CYP2D6LMNATSHRPKM
SCHEMBL9499497 0.72 MAPK1 (0.35) CYP2D6LMNATSHRMAPK1CYP3A4
SCHEMBL2270141 0.72 TSHR (0.39) KCNN4CYP2D6LMNATSHRHRH1
SCHEMBL8710885 0.71 KCNN4 (0.41) KCNN4CYP2D6LMNATSHRCHRM2
SCHEMBL2103817 0.70 KCNN4 (0.33) KCNN4
SCHEMBL8631558 0.70 MAPK1 (0.33) LMNATSHRMAPK1CYP3A4ALOX15
SCHEMBL2103508 0.69 MEN1 (0.37) CYP2D6CHRM2ADRA1ACHRM1CHRM3
SCHEMBL18398 0.69 MAPK1 (0.36) KCNN4CYP2D6LMNATSHRMAPK1
SCHEMBL2101602 0.69 TSHR (0.41) KCNN4CYP2D6LMNATSHRCHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8404584-B2 Method of manufacturing semiconductor device FUJITSU LIMITED (JP) 2013-03-26 US disclosed
US-20110207319-A1 METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE FUJITSU LIMITED (JP) 2011-08-25 US disclosed