SCHEMBL2273007

SCHEMBL2273007

CC(C)(C)OC(=O)c1ccc(N2CCC(c3ccccc3)CC2)cc1NC(=O)c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MALT1 Q9UDY8 1/20 0.45
SMN1; SMN2 Q16637 3/20 0.42
PLA2G1B P04054 1/20 0.42
ATG4B Q9Y4P1 1/20 0.42
HDAC3 O15379 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC10 Q969S8 1/20 0.42
HDAC11 Q96DB2 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
HDAC9 Q9UKV0 1/20 0.42
HDAC5 Q9UQL6 1/20 0.42
MAPT P10636 3/20 0.41
ALDH1A1 P00352 2/20 0.41
HSD17B10 Q99714 2/20 0.41
NR1H2 P55055 1/20 0.41
NR1H3 Q13133 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27716611 0.90 MALT1 (0.44) MALT1SMN1; SMN2PLA2G1BATG4BHDAC3
SCHEMBL2275234 0.85 MALT1 (0.51) MALT1SMN1; SMN2PLA2G1BATG4BHDAC3
SCHEMBL14428266 0.79 IP6K1 (0.45) MALT1SMN1; SMN2PLA2G1BATG4BHDAC3
SCHEMBL2273439 0.79 SERPINE1 (0.46) SMN1; SMN2PLA2G1BATG4BMAPTALDH1A1
SCHEMBL2271156 0.77 SMN1; SMN2 (0.45) SMN1; SMN2PLA2G1BATG4BMAPTALDH1A1
SCHEMBL2270158 0.75 MAPK1 (0.50) HDAC1MAPTALDH1A1HSD17B10HPGD
SCHEMBL12118198 0.75 HDAC1 (0.46) SMN1; SMN2HDAC1MAPTALDH1A1HSD17B10
SCHEMBL12117807 0.74 BACE1 (0.41) MALT1HDAC3HDAC1HDAC2GPR119
SCHEMBL1316807 0.74 HDAC1 (0.42) HDAC3HDAC1HDAC2GPR119
SCHEMBL2273129 0.74 PDE11A (0.41) MAPTALDH1A1HSD17B10NR1H2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 MALT1 3359/4885SMN1; SMN2 3544/4885PLA2G1B 1998/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.