SCHEMBL2273129

SCHEMBL2273129

CC(C)(C)OC(=O)c1ccc(-n2ccc3ccccc32)cc1NC(=O)c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE11A Q9HCR9 1/20 0.41
PDE10A Q9Y233 1/20 0.41
MAPK1 P28482 2/20 0.41
KDM4E B2RXH2 2/20 0.41
HSD17B10 Q99714 1/20 0.41
F10 P00742 2/20 0.40
F9 P00740 1/20 0.40
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
MEN1 O00255 1/20 0.39
MAPT P10636 1/20 0.39
PKM P14618 1/20 0.39
GRIK1 P39086 1/20 0.39
KMT2A Q03164 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
NR1H2 P55055 3/20 0.38
PYGL P06737 1/20 0.38
PYGM P11217 1/20 0.38
SMO Q99835 1/20 0.37
BRPF1 P55201 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27716722 0.90 ALDH1A1 (0.41) PDE11APDE10AMAPK1KDM4EHSD17B10
SCHEMBL2274028 0.85 PKM (0.52) PDE11APDE10AF10F9NPC1
SCHEMBL2275322 0.83 FGFR1 (0.52) PDE11APDE10AF10F9NPC1
SCHEMBL2273439 0.83 SERPINE1 (0.46) MAPK1KDM4EHSD17B10NPC1RAB9A
SCHEMBL14428468 0.83 MEN1 (0.44) PDE11APDE10AMAPK1KDM4EHSD17B10
SCHEMBL4215658 0.80 AHR (0.41) KDM4EHSD17B10F10F9NPC1
SCHEMBL14428241 0.78 TOP1 (0.47) MAPK1KDM4EF10F9MEN1
SCHEMBL2270158 0.77 MAPK1 (0.50) MAPK1KDM4EHSD17B10NPC1RAB9A
SCHEMBL31464044 0.76 BIRC5 (0.49) RAB9A
SCHEMBL28604507 0.76 KDM4E (0.48) KDM4EHSD17B10F10F9NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 PDE11A 4058/4885PDE10A 2724/4885MAPK1 168/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.