Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 1/20 | 0.71 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.71 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.71 |
| ▸ | MPO | P05164 | 7/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.50 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29504977 | 0.84 | MPO (0.74) | YAP1TEAD4TEAD2MPORXFP1 | |
| SCHEMBL22719595 | 0.84 | MPO (0.74) | YAP1TEAD4TEAD2MPORXFP1 | |
| SCHEMBL30197844 | 0.83 | YAP1 (1.00) | YAP1TEAD4TEAD2MPORXFP1 | |
| SCHEMBL22731881 | 0.83 | YAP1 (1.00) | YAP1TEAD4TEAD2MPORXFP1 | |
| SCHEMBL25466740 | 0.80 | YAP1 (0.68) | YAP1TEAD4TEAD2MPORXFP1 | |
| SCHEMBL22719612 | 0.78 | YAP1 (0.65) | YAP1TEAD4TEAD2MPORXFP1 | |
| SCHEMBL29505020 | 0.78 | YAP1 (0.65) | YAP1TEAD4TEAD2MPORXFP1 | |
| SCHEMBL22731808 | 0.76 | YAP1 (0.62) | YAP1TEAD4TEAD2MPORXFP1 | |
| SCHEMBL24143254 | 0.74 | AKR1C3 (0.76) | YAP1TEAD4TEAD2MPORXFP1 | |
| SCHEMBL22719664 | 0.73 | TEAD4 (0.68) | YAP1TEAD4TEAD2MPORXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230148061-A1 | TEAD INHIBITORS AND USES THEREOF | THE EHE FOUNDATION | 2023-05-11 | — | — | US | disclosed |
| WO-2020243423-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2020-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230148061-A1 | TEAD INHIBITORS AND USES THEREOF | TEAD2, TEAD3, TEAD4 | YAP1 111/4885TEAD4 3/4885TEAD2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.