Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | CBFB | Q13951 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.35 |
| ▸ | FABP6 | P51161 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6824048 | 0.68 | MEN1 (0.54) | MAPTTP53MEN1KMT2ALMNA | |
| SCHEMBL6824543 | 0.68 | AR (0.49) | MAPTMEN1KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL30983222 | 0.67 | PIN1 (0.45) | MAPTEGLN1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4199869 | 0.64 | TP53 (0.43) | MAPTTP53CYP1A2ALDH1A1KDM4E | |
| SCHEMBL24012942 | 0.64 | MEN1 (0.56) | MAPTTP53MEN1KMT2ALMNA | |
| SCHEMBL862325 | 0.63 | TDP1 (0.59) | MAPTKMT2ALMNACYP1A2ALDH1A1 | |
| SCHEMBL28782688 | 0.63 | BRD4 (0.47) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL25932249 | 0.63 | DHFR (0.46) | MAPTTP53METAP2METAP1CBFB | |
| Hydrochloric Acid SCHEMBL970862 | 0.62 | TDP1 (0.57) | MAPTMEN1KMT2ALMNACYP1A2 | |
| SCHEMBL17397891 | 0.61 | LMNA (0.44) | MAPTTP53MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243459-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-12-03 | — | — | WO | disclosed |