SCHEMBL2273505

SCHEMBL2273505

CN[Si](c1ccccc1)(C(C)(C)C)C(C)(C)C

nearest known ligand 0.36

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 1/20 0.36
LMNA P02545 1/20 0.35
CYP2D6 P10635 1/20 0.35
TSHR P16473 1/20 0.35
ATM Q13315 1/20 0.32
ESR1 P03372 1/20 0.32
ESR2 Q92731 1/20 0.32
MAPK1 P28482 1/20 0.31
NR1H2 P55055 1/20 0.31
NR1H3 Q13133 1/20 0.31
KDM4E B2RXH2 1/20 0.30
CYP3A4 P08684 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2269404 0.77 KCNN4 (0.39) KCNN4LMNACYP2D6ATMESR1
SCHEMBL2101131 0.76 KCNN4 (0.36) KCNN4LMNACYP2D6TSHRATM
SCHEMBL2102688 0.73 KCNN4 (0.33) KCNN4LMNACYP2D6TSHRATM
SCHEMBL2101836 0.70 KCNN4 (0.39) KCNN4LMNACYP2D6TSHRATM
SCHEMBL49919 0.69 TSHR (0.41) KCNN4LMNACYP2D6TSHRATM
SCHEMBL29749402 0.69 ESR1 (0.37) KCNN4LMNACYP2D6TSHRATM
SCHEMBL3526796 0.69 ESR1 (0.37) KCNN4LMNACYP2D6TSHRATM
SCHEMBL2104240 0.69 TSHR (0.41) KCNN4LMNACYP2D6TSHRATM
SCHEMBL2100879 0.69 TSHR (0.41) KCNN4LMNACYP2D6TSHRATM
SCHEMBL3888384 0.69 ESR1 (0.37) KCNN4LMNACYP2D6TSHRATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8404584-B2 Method of manufacturing semiconductor device FUJITSU LIMITED (JP) 2013-03-26 US disclosed
US-20110207319-A1 METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE FUJITSU LIMITED (JP) 2011-08-25 US disclosed