SCHEMBL2269404

SCHEMBL2269404

CCN[Si](c1ccccc1)(C(C)(C)C)C(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 1/20 0.39
HTT P42858 1/20 0.34
LMNA P02545 1/20 0.33
CYP2D6 P10635 1/20 0.33
TP53 P04637 1/20 0.32
ADORA2A P29274 1/20 0.32
ADORA1 P30542 1/20 0.32
ALDH1A1 P00352 2/20 0.31
SIGMAR1 Q99720 1/20 0.31
KDM4E B2RXH2 1/20 0.31
GAA P10253 1/20 0.31
HPGD P15428 1/20 0.31
TAAR1 Q96RJ0 2/20 0.31
SLC6A2 P23975 1/20 0.31
MAPT P10636 1/20 0.31
RIPK1 Q13546 1/20 0.31
ATM Q13315 1/20 0.31
ESR1 P03372 1/20 0.30
ESR2 Q92731 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2103177 0.78 KCNN4 (0.39) KCNN4HTTLMNACYP2D6TP53
SCHEMBL2273505 0.77 KCNN4 (0.36) KCNN4LMNACYP2D6KDM4EMAPT
SCHEMBL2100791 0.75 KCNN4 (0.36) KCNN4HTTLMNACYP2D6TP53
SCHEMBL2103096 0.73 KCNN4 (0.41) KCNN4HTTLMNACYP2D6TP53
SCHEMBL2102166 0.72 KCNN4 (0.34) KCNN4TAAR1RIPK1
SCHEMBL2102177 0.72 KCNN4 (0.39) KCNN4HTTLMNATP53ADORA2A
SCHEMBL233708 0.72 KCNN4 (0.39) KCNN4HTTLMNATP53ADORA2A
SCHEMBL2268924 0.72 KCNN4 (0.39) KCNN4HTTLMNATP53ADORA2A
SCHEMBL2269585 0.71 KCNN4 (0.33) KCNN4ALDH1A1MAPT
SCHEMBL234050 0.70 ESR1 (0.38) KCNN4HTTLMNATP53ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8404584-B2 Method of manufacturing semiconductor device FUJITSU LIMITED (JP) 2013-03-26 US disclosed
US-20110207319-A1 METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE FUJITSU LIMITED (JP) 2011-08-25 US disclosed