Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24882512 | 0.84 | SIGMAR1 (0.47) | LMNAPKMCNR1HPGDNAMPT | |
| SCHEMBL13328249 | 0.80 | LMNA (0.60) | LMNAPKMCNR1HPGDNAMPT | |
| SCHEMBL7257878 | 0.78 | ALDH1A1 (0.58) | LMNAPKMCNR1HPGDNAMPT | |
| SCHEMBL20112840 | 0.77 | ALDH1A1 (0.44) | LMNAPKMCNR1HPGDNAMPT | |
| SCHEMBL25029220 | 0.77 | CNR1 (0.46) | LMNAPKMCNR1HPGDNAMPT | |
| SCHEMBL25028346 | 0.77 | CNR1 (0.46) | LMNAPKMCNR1HPGDNAMPT | |
| SCHEMBL17301565 | 0.77 | LMNA (0.57) | LMNAPKMCNR1HPGDNAMPT | |
| SCHEMBL8847697 | 0.77 | CNR1 (0.67) | LMNAPKMCNR1HPGDNAMPT | |
| SCHEMBL17660248 | 0.77 | EPHX2 (0.49) | HPGDRAB9AGLA | |
| SCHEMBL11452609 | 0.76 | ALDH1A1 (0.61) | LMNAPKMCNR1HPGDNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |